Patients with major depressive disorder remain at risk for relapse following remission and
often continue to experience subthreshold symptoms. This study compared the rate of …

Objective: Although continuing antidepressant treatment after patients have responded to
medication has been shown to greatly reduce the risk of relapse, this risk is not eliminated. A …

Background: The goal was to examine predictors of relapse during continuation/
maintenance treatment of major depression that had remitted following 12 to 14 weeks of …

Objective: Loss of response to a previously effective antidepressant is a common clinical
problem. Retrospective analyses have shown that the pattern of response during …

Background: Anecdotal reports concerning mood disorder patients suggest restarting drug
treatment in patients who prematurely discontinue it may be associated with a diminished …

Relapse of major depressive disorder (MDD) is a common clinical problem. Identifying
relapse predictors could lead to strategies that reduce relapse risk. This study is designed to …

Background: Many patients with major depressive disorder (MDD) who achieve full
remission after antidepressant treatment still have residual depressive symptoms. In this …

This study assessed the effect of general medical comorbidity on response to next-step
antidepressant treatments among subjects with major depressive disorder whose …

Background Although several studies have examined the long-term efficacy of
antidepressants, relatively little attention has been paid to the management of relapses or …

Objective: The purpose of this study was to determine prospectively the optimal length of
therapy in a long-term, placebo-controlled continuation study of patients who responded to …