Homocysteine–from disease biomarker to disease prevention

AD Smith, H Refsum - Journal of internal medicine, 2021 - Wiley Online Library
We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Trends in clinical laboratory homocysteine testing from 1997 to 2010: the impact of evidence on clinical practice at a single institution

CM Klykov, SR Lentz - Clinical chemistry and laboratory medicine, 2013 - degruyter.com
Background: During the past decade, several clinical trials investigating the potential
benefits of homocysteine-lowering therapy for the secondary prevention of vascular events …

An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise?

JG Ray, DEC Cole, SC Boss - Clinical biochemistry, 2000 - Elsevier
Background: Plasma homocysteine has been reported to be useful in the evaluation of
patients with suspected vitamin B12 or folate deficiency. In November 1998, Canada began …

Short-term and long-term variability of plasma homocysteine measurement

UC Garg, ZJ Zheng, AR Folsom, YS Moyer… - Clinical …, 1997 - academic.oup.com
Within-person and methodological variability of a given analyte are important elements in
determining whether an individual has altered concentrations of that analyte. We report the …

Performance characteristics of six homocysteine assays

SL La'ulu, ML Rawlins, CM Pfeiffer… - American journal of …, 2008 - academic.oup.com
Elevated concentrations of homocysteine (Hcy) are associated with a range of disorders.
Linearity, imprecision, interference, method comparison, and accuracy were evaluated on …

Plasma homocysteine measurement: a study of pre-analytical conditions for total plasma homocysteine determination

V Ducros, M Candito, E Causse, R Couderc… - Annales de biologie …, 2001 - jle.com
An increase in homocysteine, a sulphur amino acid, is nowdays considered as a risk factor
for cardiovascular diseases, and is independent of other risk factors. Reference range for …

Homocysteine—a retrospective and prospective appraisal

A McCaddon, JW Miller - Frontiers in Nutrition, 2023 - frontiersin.org
The biologically important amino acid homocysteine links sulfur, methionine, and one-
carbon metabolism. This review describes its initial discovery, the identification of the clinical …

Short-term variability in the measurement of plasma homocysteine, fasting and post-methionine loading

MY Tsai, P McGovern, EL Kennedy, NQ Hanson - Clinical Biochemistry, 2001 - Elsevier
Objectives: Hyperhomocysteinemia is associated with premature cerebral, peripheral and
coronary vascular disease. Evaluation of the significance of changes in plasma total …

[PDF][PDF] Pre-Analytical Errors in Blood Homocysteine Assays

AS Yadav, VR Bhagwat - A1 Ameen J Med Sci, 2009 - academia.edu
Blood homocysteine is a major biomarker for cardiovascular as well as other disorders.
Several published studies reported inconsistent homocysteine levels with variable ranges …

Optimal time interval between repeated blood sampling for measurements of total homocysteine in healthy individuals

A Voortman, A Melse-Boonstra, JM Schulz… - Clinical …, 2001 - academic.oup.com
Many studies have shown that increased plasma concentrations of total homocysteine (tHcy)
are associated with cardiovascular disease (1). Like most biological variables, plasma tHcy …