To gain insight into how a naturally occurring scaffold composed of extracellular matrix
(ECM) proteins provides directional guidance for capillary sprouting, we examined …

Materials and methods Capillary sprouting in rat mesentery was studied for three angiogenic
stimuli. In the first, normal maturation from juvenile to young adult, microvessel density …

During angiogenesis, anastomosing capillary sprouts align to form complex three-
dimensional networks of new blood vessels. Using an endothelial cell spheroid model that …

During angiogenesis, endothelial cells (ECs) degrade their surrounding extracellular matrix
(ECM) to facilitate invasion. How interactions between ECs and other cells within their …

Sprouting angiogenesis is a multistep process consisting of basement membrane
degradation, endothelial cell (EC) activation, proliferation, invasion, lumen formation, and …

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular
basement membrane (BM) and the interstitial ECM is identified as a crucial component of …

Previous work has shown that endothelial cell (EC)-derived matrix metalloproteinases
(MMPs) regulate regression of capillary tubes in vitro in a plasmin-and MMP-1 dependent …

To investigate mechanisms of capillary network remodeling, we developed a serum-free
angiogenesis in vitro system in three-dimensional fibrin matrices which allows the study of …

Developing therapies aimed at manipulating microvascular remodeling requires a better
understanding of angiogenesis and how angiogenesis relates to other network remodeling …

To investigate the participation of microvascular pericytes in the process of capillary
sprouting, we examined whole-mount preparations of the rat mesentery by use of a double …