The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function

P Miodini, L Fioravanti, G Di Fronzo… - British journal of …, 1999 - nature.com
We compared the oestrogenic and anti-oestrogenic properties of the two well-known phyto-
oestrogens, genistein and quercetin, on the oestrogen-sensitive breast cancer cell line MCF …

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro

DT Zava, G Duwe - 1997 - Taylor & Francis
Experimental and epidemiologic studies support the view that soyfoods prevent cancer as
well as diseases and symptoms associated with estrogen deficiency. Recent research …

The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor

H van der Woude, MGR Ter Veld… - Molecular nutrition & …, 2005 - Wiley Online Library
Quercetin causes biphasic modulation of the proliferation of specific colon and mammary
cancer cells. In this study, the possible involvement of the estrogen receptor (ER) in the …

Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer

PJ Magee, IR Rowland - British Journal of Nutrition, 2004 - cambridge.org
The incidence of hormone-dependent cancers, such as those of the breast and prostate, is
much lower in Eastern countries such as China and Japan in comparison with the Western …

Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen

FV So, N Guthrie, AF Chambers, KK Carroll - Cancer letters, 1997 - Elsevier
The flavonoids are a group of naturally-occurring, low molecular weight compounds that are
widespread in plants. Representatives of several different classes of flavonoids were tested …

Inhibitory effect of quercetin on OVCA 433 cells and presence of type II oestrogen binding sites in primary ovarian tumours and cultured cells

G Scambia, FO Ranelletti, PB Panici, M Piantelli… - British journal of …, 1990 - nature.com
We investigated the effect of the flavonoid quercetin (Q) on the proliferation of the ovarian
cancer cell line OVCA 433. Growth experiments demonstrated that Q exerted a reversible …

Modulation of estrogen receptor-β isoforms by phytoestrogens in breast cancer cells

V Cappelletti, P Miodini… - International …, 2006 - spandidos-publications.com
High consumption of phytoestrogen-rich food correlates with reduced incidence of breast
cancer. However, the effect of phytoestrogens on growth of pre-existing breast tumors …

Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERα/ERβ ratio

AM Sotoca, D Ratman, P Van Der Saag, A Ström… - The Journal of steroid …, 2008 - Elsevier
This study investigates the importance of the intracellular ratio of the two estrogen receptors
ERα and ERβ for the ultimate potential of the phytoestrogens genistein and quercetin to …

Estrogenic and antiestrogenic activities of flavonoidphytochemicals through estrogen receptorbinding-dependent and-independent mechanisms

BM Collins-Burow, ME Burow, BN Duong… - Nutrition and …, 2000 - Taylor & Francis
Members of the flavonoid class of phytochemicals have previously been demonstrated to
possess estrogenic activity in a number of hormonally responsive systems. We have …

Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids

JC Le Bail, F Varnat, JC Nicolas, G Habrioux - Cancer Letters, 1998 - Elsevier
The interaction between the estrogen receptor and a variety of flavonoids was studied in the
presence or absence of estradiol using a stably-transfected human breast cancer cell line …