Pericellular degradation of interstitial collagens is a crucial event for cells to migrate through
the dense connective tissue matrices, where collagens exist as insoluble fibers. A key …

Up-regulation of the collagenolytic membrane type-1 matrix metalloproteinase (MT1-MMP)
leads to increased MMP2 (gelatinase A) activation and MT1-MMP autolysis. The …

Fibroblasts degrade type I collagen, the major extracellular protein found in mammals,
during events ranging from bulk tissue resorption to invasion through the three-dimensional …

Degradation of collagen is important for the physiological remodeling of connective tissues
during growth and development as well as in wound healing, inflammatory diseases, and …

Activation of proMMP-2 and cell surface collagenolysis are important activities of membrane-
type 1 matrix metalloproteinase (MT1-MMP) to promote cell migration in tissue, and these …

Homodimerization of the membrane-bound collagenase MT1-MMP [membrane-type 1 MMP
(matrix metalloproteinase)] is crucial for its collagenolytic activity. However, it is not clear …

Membrane type-1 matrix metalloproteinase (MT1-MMP) drives cell invasion through three-
dimensional (3-D) extracellular matrix (ECM) barriers dominated by type I collagen or fibrin …

The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

Degradation of collagen is required for the physiological remodelling of connective tissues
during growth and development, as well as in wound healing, inflammatory diseases, and …

The important and distinct contribution that membrane type 2 (MT2)-matrix
metalloproteinase (MMP) makes to physiological and pathological processes is now being …