During pathologic vessel remodeling, vascular smooth muscle cells (VSMCs) embedded
within the collagen-rich matrix of the artery wall mobilize uncharacterized proteolytic systems …

The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

The growth and regression of capillary blood vessels during angiogenesis is greatly
influenced by changes in the activity of matrix metalloproteinases (MMPs), which selectively …

Matrix metalloproteinase-(MMP-9) is involved in processes that occur during cutaneous
wound healing such as inflammation, matrix remodeling, and epithelialization, To …

Background—The matrix-degrading activity of matrix metalloproteinases (MMPs), required
for cell migration and general tissue reshaping, is thought essential for pathological arterial …

Matrix metalloproteinases (MMPs) are hypothesized to play a key role in the processes of
endothelial cell migration and matrix remodeling during angiogenesis. We utilized an in vitro …

Abstract Matrix metalloproteinase-3 (MMP-3) participates in normal extracellular matrix
turnover during embryonic development, organ morphogenesis and wound healing, and in …

Vascular remodeling, defined as lasting structural changes in the vessel wall in response to
hemodynamic stimuli, plays a role in many (patho) physiological processes requiring cell …

Enzymatic processing of extracellular matrix (ECM) macromolecules by matrix
metalloproteases (MMPs) is crucial in mediating physiological and pathological cell …

The turnover of native collagen has been ascribed to different members of the matrix
metalloproteinase (MMP) family. Here, the mechanisms by which neutrophil collagenase …