We examined the role of the serine proteinase plasmin in regulating fibroblast-mediated
tissue remodeling during wound healing. As an in vitro model system, collagen lattices were …

The respective requirements of collagen and MT1-MMP in the activation of MMP-2 by
primary fibroblast cultures were explored further. Three-dimensional gels enriched in human …

Interstitial collagen mechanical and biological properties are altered by proteases that
catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in …

During tissue-invasive events, migrating cells penetrate type I collagen-rich interstitial
tissues by mobilizing undefined proteolytic enzymes. To screen for members of the matrix …

Collagenase-3 (MMP-13) is a matrix metalloproteinase capable of cleaving a multitude of
extracellular matrix proteins in addition to fibrillar collagens. Human MMP-13 is expressed …

Exposure of endothelial cells (ECs) to hypoxia has separately been shown to induce their
angiogenesis or death. Matrix metalloproteinase (MMP)-2 is associated with EC …

A potential physiological role of stromelysin-1 (MMP-3) in the expression or activation of
gelatinase A (MMP-2) or gelatinase B (MMP-9) in the wall of injured arteries was studied …

Background—Remodeling of the injured vascular wall is dependent on the action of several
extracellular proteases. Previous studies have shown that expression of matrix …

Breakdown of triple‐helical interstitial collagens is essential in embryonic development,
organ morphogenesis and tissue remodelling and repair. Aberrant collagenolysis may result …

Proteolysis is an intrinsic component of cutaneous wound repair and several matrix
metalloproteinases have been shown to participate in various stages of this process …