Angiogenesis and the formation of new blood vessels requires coordinated regulation of
matrix proteolysis and endothelial cell migration. Cellular proteolytic capacity is the balance …

Matrix metalloproteinase-10 (MMP-10) is expressed by macrophages and epithelium in
response to injury, but its functions in wound repair are unknown. We observed increased …

Objectives: human vein graft stenoses are caused by intimal hyperplasia, a process which is
characterised by extensive degradation and accumulation of extracellular matrix. This study …

Remodeling of fibrillar collagen in mouse tissues has been widely attributed to the activity of
collagenase-3 (matrix metalloproteinase-13 (MMP-13)), the main collagenase identified in …

Repair following injury involves a range of processes–such as re-epithelialization, scar
formation, angiogenesis, inflammation, and more–that function, often together, to restore …

Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of
disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and …

Matrix metalloproteinases (MMPs) have been implicated in wound healing. To analyze the
roles of MMP-9 and MMP-13 in wound healing, we generated full-thickness cutaneous …

Matrix metalloproteinases (MMPs) are endopeptidases that degrade extracellular matrix and
involved in ischemic organ injuries. The present study was designed to determine the role of …

Collagen degradation is essential for cell migration, proliferation, and differentiation. Two
key turnover pathways have been described for collagen: intracellular cathepsin-mediated …

Vessel maturation during angiogenesis (the formation of new blood vessels) is
characterized by the deposition of new basement membrane and the downregulation of …