Multiple effector cells have been implicated in transplant rejection, including cytotoxic T
cells, B cells, macrophages and NK cells. 1 The purpose of this study was to examine the …

Acute allograft rejection is a major complication postlung transplantation and is the main risk
factor for the development of bronchiolitis obliterans syndrome. Acute rejection is …

Background. Innate immunity provides obstacles to successful organ transplantation, which
cannot be prevented by cyclosporine (CsA). Here we have determined the potential of a …

Rationale: Although mesenchymal stem cell (MSC) transplantation has been shown to
promote cardiac repair in acute myocardial injury in vivo, its overall restorative capacity …

T lymphocytes play a critical role in chronic rejection of transplanted hearts, or cardiac
allograft vasculopathy (CAV). However, the molecular mediators of T lymphocyte recruitment …

The development of immunosuppressive drugs to control adaptive immune responses has
led to the success of heart transplantation as a therapy for end-stage heart failure. However …

After cardiac transplantation, graft damage occurs secondary to ischemia-reperfusion injury
and acute rejection. This damage ultimately leads to the development of graft coronary …

The rate of graft survival has dramatically increased using calcineurin inhibitors, however
chronic graft rejection and risk of infection are difficult to manage. Induction of allograft …

Heart disease is not only the leading cause of death, disability, and healthcare expense in
the US, but also the leading cause of death worldwide. Therefore, treatments to lessen …

Background—CXC-chemokine receptor 4 (CXCR4) regulates the retention of
stem/progenitor cells in the bone marrow (BM), and the CXCR4 antagonist AMD3100 …