Macrophages infiltrating the allografts are heterogeneous, consisting of proinflammatory (M1
cells) as well as antiinflammatory and fibrogenic phenotypes (M2 cells); they affect …

Background. Immune-mediated injury to the graft has been implicated in the pathogenesis of
chronic rejection. However, little is known regarding the nature of the antigen (s) involved in …

Ab-mediated lymphoablation is commonly used in solid organ and hematopoietic cell
transplantation. However, these strategies fail to control pathogenic memory T cells …

Hamid and Prabhu Immunomodulation and Cardiac Repair 1531 intravenous route to
sustain reparative responses over the long term. Such a paradigm would greatly facilitate …

The lymph node (LN) is the primary site of alloimmunity activation and regulation during
transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the …

The induction of specific tolerance would be the ultimate achievement in transplant
immunology, but the precise mechanisms of immunologic tolerance remain largely …

Cardiac allograft vasculopathy (CAV) is a major source of late posttransplant mortality.
Although numerous cell types are implicated in the pathogenesis of CAV, it is unclear which …

Ischemia reperfusion injury (IRI) is an unavoidable event during solid organ transplantation
and is a major contributor to early graft dysfunction and subsequent graft immunogenicity. In …

In the infarcted myocardium, cardiomyocyte necrosis triggers an intense inflammatory
reaction that not only is critical for cardiac repair, but also contributes to adverse remodeling …

Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts within 12–24
h posttransplant in mice and are activated to proliferate and produce IFN-γ. To more …