Convective transport can significantly distort spatial concentration gradients. Interstitial flow
is ubiquitous throughout living tissue, but our understanding of how interstitial flow affects …

A crucial yet ill-defined phenomenon involved in the remodeling of vascular networks,
including angiogenic sprouting, is flow-mediated endothelial dynamics and phenotype …

Hemodynamic and biochemical factors play important roles in critical steps of angiogenesis.
In particular, interstitial flow has attracted attention as an important hemodynamic factor …

Cell organization is largely orchestrated by extracellular gradients of morphogenetic
proteins. VEGF, an essential factor for capillary formation, is stored in the extracellular …

Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This
creeping fluid flow has been shown to affect the morphology and migration of cells such as …

Whereas high shearing flows are known to induce endothelial cell remodeling, we show
here that very low interstitial flow rates trigger endothelial cell morphogenesis in 3D cultures …

Interstitial flow is an important biophysical cue that can affect capillary morphogenesis, tumor
cell migration, and fibroblast remodeling of the extracellular matrix, among others. Current …

Dynamic stresses that are present in all living tissues drive small fluid flows, called interstitial
flows, through the extracellular matrix. Interstitial flow not only helps to transport nutrients …

Efficient delivery of oxygen and nutrients to tissues requires an intricate balance of blood,
lymphatic, and interstitial fluid pressures (IFPs), and gradients in fluid pressure drive the flow …

Interstitial flow is an important component of the microcirculation and interstitial environment,
yet its effects on cell organization and tissue architecture are poorly understood, in part due …