Extracellular ATP controls various signaling systems including propagation of intercellular
Ca2+ signals (ICS). Connexin hemichannels, P2x7 receptors (P2x7Rs), pannexin channels …

Abstract Connexin 26 (Cx26) and connexin 30 (Cx30) form hemichannels that release ATP
from the endolymphatic surface of cochlear supporting and epithelial cells and also form gap …

In the cochlea, extracellular ATP influences the endocochlear potential, micromechanics,
and neurotransmission via P2 receptors. Evidence for this arises from studies demonstrating …

Connexin gap junctions play an important role in hearing function, but the mechanism by
which this contribution occurs is unknown. Connexins in the cochlea are expressed only in …

Extracellular ATP has multimodal actions in the cochlea affecting hearing sensitivity. ATP-
gated ion channels involved in this process were characterized in the guinea pig cochlea …

Extracellular ATP is a key neuromodulator of visual and auditory sensory epithelia. In the rat
cochlea, pharmacological dissection indicates that ATP, acting through a highly sensitive …

The sense of hearing is remarkable for its auditory dynamic range, which spans more than
1012 in acoustic intensity. The mechanisms that enable the cochlea to transduce high sound …

Connexin hemichannels have been proposed as a diffusion pathway for the release of
extracellular messengers like ATP and others, based on connexin expression models and …

Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30
accounts for nearly half of all cases of hereditary nonsyndromic deafness cases. Although it …

Normal development, function and repair of the sensory epithelia in the inner ear are all
dependent on gap junctional intercellular communication. Mutations in the connexin genes …