A gap junction is composed of two hemichannels and possesses a relatively large pore size
(∼ 10–15 Å), allowing passage of ions and molecules up to 1 kDa. Here, we report that …

Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-
assemble to form gap junctions (GJs) in the cochlea. Mutations in either one of them are the …

Intercellular communication is important for cochlear homeostasis because connexin26
(Cx26) mutations are the leading cause of hereditary deafness. Gap junctions formed by …

Gap junction channels formed by different connexins exhibit specific permeability to a variety
of larger solutes including second messengers, polypeptides, and small interfering RNAs …

Gap junctions are thought to mediate the direct intercellular coupling of adjacent cells by the
open-closed gating of an aqueous pore permeable to ions and molecules of up to 1 kDa or …

Several different recessive mutations in the connexin26 (Cx26; β2) gene have been
associated with non‐syndromic hereditary deafness. This suggests gap junctions are …

Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30
accounts for nearly half of all cases of hereditary nonsyndromic deafness cases. Although it …

Gap junctions play a critical role in hearing and mutations in connexin genes cause a high
incidence of human deafness. Pathogenesis mainly occurs in the cochlea, where gap …

Gap junction channels assembled from connexin protein subunits mediate intercellular
transfer of ions and metabolites. Impaired channel function is implicated in several …

Gap junction channels have long been viewed as static structures containing a large-
diameter, aqueous pore. This pore has a high permeability to hydrophilic molecules of≈ …