The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males

T Ishikubo, Y Nishimura, K Yamaguchi, U Khansuwan… - Cancer letters, 2004 - Elsevier
Colorectal cancers with high-frequency microsatellite instability (MSI-H) are known to
display striking differences in their clinical and pathological features compared to …

[HTML][HTML] Concordance between microsatellite instability and mismatch repair protein expression in colorectal cancer and their clinicopathological characteristics: a …

M Ye, G Ru, H Yuan, L Qian, X He, S Li - Frontiers in Oncology, 2023 - frontiersin.org
Microsatellite instability (MSI) is one of the hallmarks of colorectal cancer (CRC). Mismatch
repair (MMR) protein expression may reflect MSI status. To analyze the concordance …

Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer

J Shia, NA Ellis, PB Paty, GM Nash, J Qin… - The American journal …, 2003 - journals.lww.com
Identification of colorectal carcinomas with high levels of DNA microsatellite instability (MSI-
H) is important because of the suggested prognostic and therapeutic significance associated …

Higher frequency of diploidy in young-onset microsatellite-stable colorectal cancer

LA Boardman, RA Johnson, GM Petersen… - Clinical cancer …, 2007 - AACR
Purpose: Colorectal carcinoma (CRC) can be divided into two nonoverlapping groups: those
that are chromosomally unstable but microsatellite stable (MSS CIN+) and those that are …

Automated, multiplex assay for high-frequency microsatellite instability in colorectal cancer

GM Nash, M Gimbel, J Shia, AT Culliford… - Journal of clinical …, 2003 - ascopubs.org
Purpose: In a series of hereditary nonpolyposis colorectal cancer (HNPCC) patients, we
evaluated the sensitivities of the individual microsatellites recommended by the National …

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

RN Jorissen, L Lipton, P Gibbs, M Chapman… - Clinical cancer …, 2008 - AACR
Purpose: About 15% of colorectal cancers harbor microsatellite instability (MSI). MSI-
associated gene expression changes have been identified in colorectal cancers, but little …

Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers–ready for prime time?

K Søreide - Tumor Biology, 2007 - karger.com
Microsatellite instability (MSI) is a genetic feature of colorectal cancer (CRC) associated with
peculiar clinicopathological features and improved prognosis. It is demonstrated in> 90% of …

Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers

Y Abe, H Masuda - Journal of surgical oncology, 2000 - Wiley Online Library
Abstract Background and Objectives The purpose of this study was to elucidate genetic
alterations of sporadic colorectal cancers with Microsatellite instability (MSI). Methods One …

[HTML][HTML] Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin

M Pinheiro, T Ahlquist, SA Danielsen, GE Lind, I Veiga… - BMC cancer, 2010 - Springer
Background Only a few studies have addressed the molecular pathways specifically
involved in carcinogenesis of the distal colon and rectum. We aimed to identify potential …

[HTML][HTML] Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas

A Blanes, SJ Diaz-Cano - World journal of gastroenterology: WJG, 2006 - ncbi.nlm.nih.gov
Microsatellite instability (MSI) is a prognostic factor and a marker of deficient mismatch repair
(MMR) in colorectal adenocarcinomas (CRC). However, a proper application of this marker …