Bright ideas for chemical biology
Small-molecule fluorescent probes embody an essential facet of chemical biology. Although
numerous compounds are known, the ensemble of fluorescent probes is based on a modest …
numerous compounds are known, the ensemble of fluorescent probes is based on a modest …
Evolution of fluorescein as a platform for finely tunable fluorescence probes
Y Urano, M Kamiya, K Kanda, T Ueno… - Journal of the …, 2005 - ACS Publications
Fluorescence imaging is the most powerful technique currently available for continuous
observation of dynamic intracellular processes in living cells. Suitable fluorescence probes …
observation of dynamic intracellular processes in living cells. Suitable fluorescence probes …
Caveat fluorophore: an insiders' guide to small-molecule fluorescent labels
JB Grimm, LD Lavis - Nature Methods, 2022 - nature.com
The last three decades have brought a revolution in fluorescence microscopy. The
development of new microscopes, fluorescent labels and analysis techniques has pushed …
development of new microscopes, fluorescent labels and analysis techniques has pushed …
Improved chemical-genetic fluorescent markers for live cell microscopy
Inducible chemical-genetic fluorescent markers are promising tools for live cell imaging
requiring high spatiotemporal resolution and low background fluorescence. The …
requiring high spatiotemporal resolution and low background fluorescence. The …
Bright photoactivatable fluorophores for single-molecule imaging
Small-molecule fluorophores are important tools for advanced imaging experiments. We
previously reported a general method to improve small, cell-permeable fluorophores which …
previously reported a general method to improve small, cell-permeable fluorophores which …
Reaction-based small-molecule fluorescent probes for chemoselective bioimaging
The dynamic chemical diversity of elements, ions and molecules that form the basis of life
offers both a challenge and an opportunity for study. Small-molecule fluorescent probes can …
offers both a challenge and an opportunity for study. Small-molecule fluorescent probes can …
Chronological development of functional fluorophores for bio-imaging
Functional fluorophores represent an emerging research field, distinguished by their diverse
applications, especially in sensing and cellular imaging. After the discovery of Quinine …
applications, especially in sensing and cellular imaging. After the discovery of Quinine …
A general method to improve fluorophores for live-cell and single-molecule microscopy
Specific labeling of biomolecules with bright fluorophores is the keystone of fluorescence
microscopy. Genetically encoded self-labeling tag proteins can be coupled to synthetic dyes …
microscopy. Genetically encoded self-labeling tag proteins can be coupled to synthetic dyes …
Photoactivatable and photoconvertible fluorescent probes for protein labeling
D Maurel, S Banala, T Laroche… - ACS chemical biology, 2010 - ACS Publications
Photosensitive probes are powerful tools to study cellular processes with high temporal and
spatial resolution. However, most synthetic fluorophores suited for biomolecular imaging …
spatial resolution. However, most synthetic fluorophores suited for biomolecular imaging …
Miniaturized chemical tags for optical imaging
Recent advances in optical bioimaging have prompted the need for minimal chemical
reporters that can retain the molecular recognition properties and activity profiles of …
reporters that can retain the molecular recognition properties and activity profiles of …