In this study, we describe a model of opiate sensitization characterized by a brief schedule of
treatment with repeated morphine administrations. In this model, we investigated the …

The nucleus accumbens has been subdivided into a shell and a core compartment on the
basis of histochemical and connectional differences. Recently, we reported that behavioral …

Repeated exposure to drugs of abuse causes persistent behavioural sensitization and
associated adaptations in striatal neurotransmission, which is thought to play an important …

Rationale: The repeated administration of addictive drugs, such as amphetamine, cocaine,
and morphine, produces a progressive enhancement (sensitization) of their psychomotor …

The selectively bred Roman high-and low-avoidance rats differ in emotionality and
responsiveness to the motor effects of acute and repeated psychostimulant administration …

We have recently reported that behavioural sensitization to morphine, amphetamine,
cocaine and nicotine is associated with an increased response of dialysate dopamine to the …

The use of inbred rat strains provides a tool to investigate the role of genetic factors in drug
abuse. Two such strains are Lewis and Fischer 344 rats. Although several biochemical and …

Alterations in dopamine transmission in the nucleus accumbens, which is composed of two
anatomically distinct compartments termed the shell and core, contribute to the expression of …

Repeated, once daily morphine treatment (14 days) as well as chronic morphine
administration (6 days) caused a rebound reduction in the electrically evoked release of [3 …

Intermittent treatment of rats with morphine (10 mg/kg sc, once daily) caused an increase (of
about 30%) of the electrically evoked release of [14C] acetylcholine from cholinergic …