The mesolimbic dopamine system, which arises in the ventral tegmental area (VTA), is an
important neural substrate for opiate reinforcement and addiction. Chronic exposure to …

The ventral tegmental area (VTA) and its dopaminergic projections appear to mediate some
of the rewarding properties of opiates, cocaine, and other drugs of abuse. In a previous …

Substantial evidence indicates that the ventral tegmental area (VTA) of the
mesocorticolimbic dopaminergic (DA) system has a key role in mechanisms of opiate …

Dopamine-containing neurons originating in the ventral tegmental area project primarily to
the nucleus accumbens and the prefrontal cortex, forming the mesolimbic and mesocortical …

Morphine withdrawal is characterized by functional alterations at the level of the
ventrotegmental area. We investigated the effects of chronic morphine administration and …

The mesolimbic dopamine system, which mediates the rewarding properties of nearly all
drugs of abuse, originates in the ventral tegmental area (VTA) and sends major projections …

A considerable body of evidence indicates that opiates have an important influence on
midbrain dopaminergic neurons. However, little data exist concerning the effects of opiates …

Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed
for 24–25 days before their brains were processed for Golgi‐Cox staining. Prior exposure to …

Microdialysis and high-performance liquid chromatography with electrochemical detection
were used to determine extracellular levels of dopamine following ventral tegmental …

Opiate addiction is a chronically relapsing disorder that is characterized by compulsive drug
taking, an inability to limit intake, and bouts of intense drug craving that can be precipitated …