Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients

A Serretti, M Kato, D De Ronchi, T Kinoshita - Molecular psychiatry, 2007 - nature.com
The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly
associated with antidepressant response in mood disorder patients, but findings are not …

Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy

S Porcelli, C Fabbri, A Serretti - European Neuropsychopharmacology, 2012 - Elsevier
In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was
likely the most studied genetic variant as predictor of antidepressant response. Nevertheless …

Antidepressant response and the serotonin transporter gene-linked polymorphic region

MJ Taylor, S Sen, Z Bhagwagar - Biological psychiatry, 2010 - Elsevier
BACKGROUND: The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has
been proposed as a predictor of antidepressant response. Insertion or deletion of a 44-base …

Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatment

MS Lee, HY Lee, HJ Lee, SH Ryu - Psychiatric genetics, 2004 - journals.lww.com
Objective This study investigates the relationship between the serotonin transporter linked
polymorphic region (5-HTTLPR) and the long-term outcome of antidepressant treatment …

Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders

YWY Yu, SJ Tsai, TJ Chen, CH Lin, CJ Hong - Molecular psychiatry, 2002 - nature.com
Abstract The serotonin transporter (5-HTT) is the site of primary action for the selective
serotonin reuptake inhibitors (SSRIs). Previous Western reports have demonstrated that the …

Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment

RH Perlis, D Mischoulon, JW Smoller, YJY Wan… - Biological …, 2003 - Elsevier
BACKGROUND: The short (S) allele of the serotonin transporter gene-linked polymorphic
region (5HTTLPR) has been associated with poorer antidepressant response in major …

Moderation of antidepressant response by the serotonin transporter gene

P Huezo-Diaz, R Uher, R Smith, M Rietschel… - The British Journal of …, 2009 - cambridge.org
BackgroundThere have been conflicting reports on whether the length polymorphism in the
promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant …

Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder

M Kato, A Serretti - Molecular psychiatry, 2010 - nature.com
This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review

KM Smits, LJM Smits, J Schouten, FF Stelma… - Molecular …, 2004 - nature.com
Large differences in clinical response to selective serotonin reuptake inhibitors (SSRIs) are
observed in depressive patients with different genotypes. Quantification of these differences …

Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder

CJ Hong, TJ Chen, YWY Yu, SJ Tsai - The pharmacogenomics journal, 2006 - nature.com
Serotonin systems appear to play a key role in the pathogenesis of major depression and
the therapeutic mechanisms of antidepressants. The firing rate of dorsal raphe serotonergic …