The therapeutic use of embryonic stem (ES)-derived cells is restricted by a risk of teratoma
formation. To test the hypothesis that some cells with pluripotency characteristics remain …

The formation of embryoid bodies (EBs) is the principal step in the differentiation of
embryonic stem (ES) cells. In this study, the morphological characteristics and gene …

The controlled differentiation of pluripotent cells will be a prerequisite for many cell
therapies. We have previously reported homogeneous conversion of embryonic stem (ES) …

Background Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts.
The murine ES cells were demonstrated to be true pluripotent cells as they differentiate into …

Embryonic stem (ES) cells are in vitro cultivated pluripotent cells derived from the inner cell
mass (ICM) of the embryonic blastocyst. Attesting to their pluripotency, ES cells can be …

Embryonic stem (ES) cells are derived from blastocyst-stage embryos. Their unique
properties of self-renewal and pluripotency make them an attractive tool for basic research …

Teratoma formation assays are established methods for evaluating the pluripotency of
embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. Teratoma formation in …

Since the early 1980s, embryonic stem (ES) cells have been isolated from the inner cell
mass of the preimplantation blastocyst (1–3). They can be maintained in a pluripotent state …

The inner cell mass of pre-implantation blastocyst stage embryos is a source of cells that can
be cultured indefinitely in vitro as a self-renewing, pluripotent population. In this review, we …

Pluripotent embryonic stem (ES) cells have the potential to form teratomas composed of
derivatives from all three germ layers in animal models. This tumorigenic potential prevents …