Systemic lupus erythematosus (SLE) is a severe autoimmune disease that is characterized
by the production of antinuclear antibodies. In particular, the response against the …

Systemic lupus erythematosus is an autoimmune disease characterized by the presence of
autoantibodies. One of the unique targets of the immune system in systemic lupus …

Autoimmunity is a serious health problem and understanding the maintenance and loss of
tolerance to self-antigens are key issues in developing new therapeutic strategies to treat …

To determine the regulation of B cells specific for the ribonucleoprotein Sm, a target of the
immune system in human and mouse lupus, we have generated mice carrying an anti-Sm H …

B lymphocytes can be divided into different subpopulations, some with distinctive activation
requirements and likely mediating specialized functions, based on surface phenotype and/or …

B cell receptors with certain heavy/light chain pairs predominate in the periphery of anti-DNA
heavy chain transgenic mice while certain other B cell receptors are absent. We wanted to …

We investigate the role of the antigen‐specific B cell receptor (BCR) in the establishment
and maintenance of the peripheral B cell pools. We studied the fate of a population of …

The presence of B cells expressing two B cell receptors (BCR), described in BCR‐
transgenic, gene‐targeted and normal mice, may represent an autoimmune hazard. We …

Selection of B cells into the mature B cell compartments is based on the affinity of the B cell
receptor (BCR) for self-ligands. Strongly self-reactive B cells undergo receptor editing or …

The commitment of a pluripotential stem cell to the B-cell lineage and the progression of the
committed B-cell precursor to a mature, immunocompetent B-cell is a highly regulated …