The nematode Caenorhabditis elegans has proved to be an excellent model organism for
the study of development and aging. Many aging mutants have been discovered in the past …

The nematode Caenorhabditis elegans has been subjected to dietary restriction (DR) by a
number of means, with varying results in terms of fecundity and lifespan. Two possible …

The nematode Caenorhabditis elegans has been subjected to DR by food (Escherichia coli)
dilution, growth in axenic medium and using animals having defects in feeding behavior or …

The first observation of the positive effect of reduced food intake on mammalian life span
was made 70 years ago (1). In the decades that followed, researchers successfully applied …

The nematode Caenorhabditis elegans continues to serve as a useful model of life
extension caused by dietary restriction. Using this model, downstream effectors of dietary …

Publisher Summary This chapter focuses on the genetic pathways that mediate longevity
induced by various dietary restriction (DR) regimens in Caenorhabditis elegans and …

Dietary restriction is known to promote longevity in a variety of eukaryotic organisms. Most
studies of dietary restriction have been performed on animals bred for many generations …

Reduction of food intake without malnutrition or starvation is known to increase lifespan and
delay the onset of various age-related diseases in a wide range of species, including …

The increased lifespan caused by food limitation has been observed in a wide range of
animals including the nematode Caenorhabditis elegans. We show here that the lifespans of …

Dietary restriction (DR) is one of the most robust environmental manipulations that not only
extend life span but also delay the onset of age-related diseases in almost every species …