Although microsatellite mutation rates generally increase with increasing length of the
repeat tract, interruptions in a microsatellite may stabilize it. We have performed a direct …

Microsatellites are DNA elements composed of short tandem repeats of 1–5bp. These
sequences are particularly prone to frameshift mutation by insertion–deletion loop formation …

We have measured the mutation rates of G17 and A17 repeat sequences in cultured
mammalian cells with and without mismatch repair and have compared these rates to those …

It is generally accepted that longer microsatellites mutate more frequently in defective DNA
mismatch repair (MMR) than shorter microsatellites. Indeed, we have previously observed …

Dinucleotide repeats, because of their repetitive nature, are prone to frameshift mutations,
most likely via a DNA-polymerase slippage mechanism. Mutation rates in microsatellite DNA …

A selectable system has been used to determine mutation rates within a microsatellite
sequence in human cancer cell lines with or without defects in mismatch repair. A sequence …

A cell culture system has been used to determine the relative rates of insertions and
deletions of integral numbers of dinucleotide repeats in a microsatellite sequence. A plasmid …

Microsatellite instability is a phenotype observed in tumors cells that have defects in DNA
mismatch repair (MMR). Most markers used for detecting microsatellite instability are mono …

DNA mismatch repair (MMR) system—MSH3, MSH6, PMS2, and the recently discovered
MLH3—contain mononucleotide microsatellites in their coding sequences. This intriguing …

Mismatch repair deficiency results in the elevation of mutation rates in tumors, which is
especially pronounced in simple repeat sequences (microsatellites). We have investigated …