Background Dietary restriction (DR) increases life span and delays age-associated disease
in many organisms. The mechanism by which DR enhances longevity is not well …

Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends
lifespan in a variety of species; however, its underlying mechanisms remain unclear. We …

Diet has a substantial impact on cellular metabolism and physiology. Animals must sense
different food sources and utilize distinct strategies to adapt to diverse diets. Here we show …

Dietary restriction appears to act as a general non-genetic mechanism that can robustly
prolong lifespan. There have however been reports in many systems of cases where …

A partial reduction in food intake has been found to increase lifespan in many different
organisms. We report here a new dietary restriction regimen in the nematode …

In Caenorhabditis elegans, several manipulations that affect nutrition slow development,
reduce fecundity, and increase life span. These are viewed as dietary restriction (DR) and …

The nematode Caenorhabditis elegans continues to serve as a useful model of life
extension caused by dietary restriction. Using this model, downstream effectors of dietary …

Dietary restriction (DR) is the most consistent means of extending life span throughout the
animal kingdom. Multiple mechanisms by which DR may act have been proposed but none …

Dietary restriction (DR) interventions have demonstrated their efficacy in extending lifespan;
however, the association between lifespan extension and health span remains unclear. This …

Diet is one of the more variable aspects in life due to the variety of options that organisms
are exposed to in their natural habitats. In the laboratory, C. elegans are raised on bacterial …