In this paper, we trace the history of current research into the genetic and biochemical
mechanisms that underlie folate‐preventable neural tube defects (NTDs). The inspired …

Neural-tube defects (NTD) are common congenital malformations that can lead to severe
disability or even death. Periconceptional supplementation with the B-vitamin folic acid has …

Neural tube defects (NTDs) are among the commonest human birth defects, affecting around
1 per 1,000 births [Copp et al., 2003]. A genetic basis for NTDs is implicated based on the …

Neural tube defects (NTDs) are the most severe congenital malformations of the central
nervous system. The etiology is complex, with both genetic and environmental factors …

Neural tube defects (NTDs) occur secondary to failed closure of the neural tube between the
third and fourth weeks of gestation. The worldwide incidence ranges from 0.3 to 200 per …

Introduction Multiple genetic and epigenetic factors involved in central nervous system
(CNS) development influence the incidence of neural tube defects (NTDs). Discussion The …

Neural tube defects (NTDs) are common congenital malformations in humans. While
etiologically heterogeneous, for the most part they are multifactorial in their pathogenesis …

Folate administration substantially reduces the risk on neural tube defects (NTD). The
interest for studying a disturbed homocysteine (Hcy) metabolism in relation to NTD was …

Periconceptional folate supplementation reduces the recurrence and occurrence risk of
neural tube defects (NTD) by as much as 70%, yet the protective mechanism remains …

Objective: To investigate the contribution of polymorphic variation in genes involved in the
folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD) …