Neural tube defects (NTDs) are common, serious malformations with a complex etiology that
suggests involvement of both genetic and environmental factors. The authors evaluated …

Neural tube defects (NTDs) are among the commonest human birth defects, affecting around
1 per 1,000 births [Copp et al., 2003]. A genetic basis for NTDs is implicated based on the …

Neural tube defects (NTDs) occur secondary to failed closure of the neural tube between the
third and fourth weeks of gestation. The worldwide incidence ranges from 0.3 to 200 per …

Neural tube defects (NTDs) are multifactorial in their etiology, having both genetic and
environmental factors contributing to their development. Recent evidence demonstrates that …

Periconceptional folic acid use can often prevent neural tube defects (NTDs). Variants of
genes involved in folate metabolism in mothers and children have been associated with …

The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …

Neural tube defects (NTDs) are the most severe congenital malformations of the central
nervous system. The etiology is complex, with both genetic and environmental factors …

It now recognized that the use of folate fortification and/or supplementation before initiation
of pregnancy can impact the risk of the fetus developing a neural tube defect. This document …

In this paper, we trace the history of current research into the genetic and biochemical
mechanisms that underlie folate‐preventable neural tube defects (NTDs). The inspired …

Neural tube defects (NTDs) are common congenital malformations in humans. While
etiologically heterogeneous, for the most part they are multifactorial in their pathogenesis …