Copyright 2000 Academic PressNF-κB is a heterodimeric transcription factor that plays a key
role in inflammatory and immune responses. In non-stimulated cells, NF-κB dimers are …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Recent investigations have elucidated the cytokine-induced NF-κB activation pathway. IκB
kinase (IKK) phosphorylates inhibitors of NF-κB (IκBs). The phosphorylation targets them for …

NF-κB is activated by various stimuli including inflammatory cytokines and stresses. A key
step in the activation of NF-κB is the phosphorylation of its inhibitors, IκBs, by an IκB kinase …

Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and
molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the …

Members of the nuclear factor kappa B (NF-κB) family of dimeric transcription factors (TFs)
regulate expression of a large number of genes involved in immune responses …

Activation of the transcription factor NF-κB is regulated by the phosphorylation and
subsequent degradation of its inhibitory subunit, IκB. A large multiprotein complex, the IκB …

The inducible transcription factor NF-κB plays a central role in the regulation of many
immune and inflammatory responses. Advances in our knowledge of the signaling …

A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK)
complex. IKKα and IKKβ are the two catalytic subunits of the IKK complex and two additional …

Extracellular stimuli that activate the transcription factor NF-κB cause rapid phosphorylation
of the IκBα inhibitor, which retains NF-κB in the cytoplasm of nonstimulated cells …