Dietary restriction appears to act as a general non-genetic mechanism that can robustly
prolong lifespan. There have however been reports in many systems of cases where …

The increased lifespan caused by food limitation has been observed in a wide range of
animals including the nematode Caenorhabditis elegans. We show here that the lifespans of …

A partial reduction in food intake has been found to increase lifespan in many different
organisms. We report here a new dietary restriction regimen in the nematode …

Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends
lifespan in a variety of species; however, its underlying mechanisms remain unclear. We …

The nematode Caenorhabditis elegans has been subjected to DR by food (Escherichia coli)
dilution, growth in axenic medium and using animals having defects in feeding behavior or …

The nematode Caenorhabditis elegans continues to serve as a useful model of life
extension caused by dietary restriction. Using this model, downstream effectors of dietary …

It has been postulated that the presence of parasites causing high extrinsic mortality may
trigger an inducible acceleration of the host aging. We tested this hypothesis using isogenic …

The survival of Caenorhabditis elegans was studied comparing animals of different sexes,
sterilized animals, and animals grown at different temperatures as a prelude to more …

Antioxidants are often investigated as a promising strategy for extending lifespan.
Accordingly, there is significant interest in novel antioxidant compounds derived from natural …

The nematode Caenorhabditis elegans has been subjected to dietary restriction (DR) by a
number of means, with varying results in terms of fecundity and lifespan. Two possible …