In the nematode Caenorhabditis elegans, loss of function of many genes leads to increases
in lifespan, sometimes of a very large magnitude. Could this reflect the occurrence of …

Demographic characteristics of the bacterial-feeding nematode Caenorhabditis elegans
were determined in two long-lived mutant strains, TJ1052 (age-1), CB4876 (clk-1), and a …

In 1967, as we became interested in the biology of aging, we were faced with the following
basic biological paradox: organisms are endowed with the capacity to detect and repair …

A major feature of aging is a reduction in muscle strength from sarcopenia, the loss of
muscle mass. Sarcopenia impairs physical ability, reduces quality of life and increases the …

Much of the recent interest in aging research is due to the discovery of genes in a variety of
model organisms that appear to modulate aging. A large amount of research has focused on …

Here, we consider that most of the research concerning Caenorhabditis elegans has been
laboratory focused and that only limited research has directly considered the worm's biology …

During the last three decades the soil nematode C. elegans has become a prominent model
organism for studying aging. Initially research in the C. elegans aging field was focused on …

Relatively simple model organisms such as yeast, fruit-flies and the nematode,
Caenorhabditis elegans, have proven to be invaluable resources in biological studies. An …

Dietary restriction (DR) delays the onset of age‐related deterioration and extends the life
span in a variety of model organisms. In many species, age changes in mortality obey the …

While much is known of the morphological and some physiological changes which occur
during the aging of Caenorhabditis elegans, little attempt has been made to measure the …