Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans

K Houthoofd, BP Braeckman, I Lenaerts, K Brys… - Experimental …, 2002 - Elsevier
Culture in axenic medium causes two-fold increases in the length of development and adult
life span in Caenorhabditis elegans. We asked whether axenic medium imposes dietary …

Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans

K Houthoofd, BP Braeckman, TE Johnson… - Experimental …, 2003 - Elsevier
Dietary restriction (DR) increases life span in a wide variety of animals. In Caenorhabditis
elegans both reduced bacterial concentration (BDR) and culture on non-bacterial, semi …

Developmental biomarkers of aging in Caenorhabditis elegans

Z Pincus, FJ Slack - … dynamics: an official publication of the …, 2010 - Wiley Online Library
The developmental process of the nematode Caenorhabditis elegans is famously invariant;
however, these animals have surprisingly variable lifespans, even in extremely …

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

MR Klass - Mechanisms of ageing and development, 1983 - Elsevier
The free-living nematode Caenorhabditis elegans is used as a genetically manipulable
experimental system for the study of aging. Utilizing a temperature-sensitive sterile strain …

The nematode Caenorhabditis elegans as a model for aging research

HID Mack, T Heimbucher, CT Murphy - Drug Discovery Today: Disease …, 2018 - Elsevier
The nematode Caenorhabditis elegans is a key model system for experimental research on
the genetic regulation of aging, and has paved the way towards many important discoveries …

Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction

NJ Szewczyk, IA Udranszky, E Kozak… - Journal of …, 2006 - journals.biologists.com
Studies of the model organism Caenorhabditis elegans have almost exclusively utilized
growth on a bacterial diet. Such culturing presents a challenge to automation of …

The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?

BP Braeckman, L Demetrius, JR Vanfleteren - Biogerontology, 2006 - Springer
Dietary restriction (DR) lengthens life span in wide range of vertebrate and invertebrate
species. The molecular mechanism by which DR increases life span and the universality of …

Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span

MR Klass - Mechanisms of ageing and development, 1977 - Elsevier
The free-living nematode Caenorhabditis elegans is an excellent experimental system for
the study of aging. The present study identifies some of the major biological and …

The effects of Bacillus subtilis on Caenorhabditis elegans fitness after heat stress

KL Hoang, NM Gerardo, LT Morran - Ecology and Evolution, 2019 - Wiley Online Library
Microbes can provide their hosts with protection from biotic and abiotic factors. While many
studies have examined how certain bacteria can increase host lifespan, fewer studies have …

Using C. elegans for aging research

HA Tissenbaum - Invertebrate reproduction & development, 2015 - Taylor & Francis
Over a century ago, the zoologist Emile Maupas first identified the nematode, Rhabditis
elegans, in the soil in Algiers. Subsequent work and phylogenic studies renamed the …