Abstract Model organisms have been widely used to study the ageing phenomenon in order
to learn about human ageing. Although the phylogenetic diversity between vertebrates and …

As in other poikilotherms, longevity in C. elegans varies inversely with temperature; worms
are longer‐lived at lower temperatures. While this observation may seem intuitive based on …

Diet has a substantial impact on cellular metabolism and physiology. Animals must sense
different food sources and utilize distinct strategies to adapt to diverse diets. Here we show …

Improving healthspan, defined as the period where organisms live without frailty and/or
disease, is a major goal of biomedical research. While healthspan measures in people are …

Background Phenotypic plasticity, ie the capacity to change the phenotype in response to
changes in the environment without alteration of the genotype, is important for coping with …

We designed a novel procedure for the isolation of mutant strains with significantly
increased life spans in the nematode Caenorhabditis elegans. This procedure involves …

More than 40 single-gene mutants in Caenorhabditis elegans have been demonstrated to
lead to increased lifespan (a rigorous, operational test for being a gerontogene) of 20% or …

More than 40 mutants in Caenorhabditis elegans have been demonstrated to lead to
increased life span (a rigorous, operational test for being a gerontogene) of 20% or more …

Bacteria serve as live food and nutrients for bacterial-feeding nematodes (BFNs) in soils,
and influence nematodes behavior and physiology through their metabolism. Five bacterial …

Dietary restriction increases life span in a wide range of species, including the nematode
worm Caenorhabditis elegans. The mechanism by which it does so remains largely …