In Caenorhabditis elegans, several manipulations that affect nutrition slow development,
reduce fecundity, and increase life span. These are viewed as dietary restriction (DR) and …

Culture in axenic medium causes two-fold increases in the length of development and adult
life span in Caenorhabditis elegans. We asked whether axenic medium imposes dietary …

Studies of the model organism Caenorhabditis elegans have almost exclusively utilized
growth on a bacterial diet. Such culturing presents a challenge to automation of …

Reduction of food intake without malnutrition or starvation is known to increase lifespan and
delay the onset of various age-related diseases in a wide range of species, including …

Dietary restriction is known to promote longevity in a variety of eukaryotic organisms. Most
studies of dietary restriction have been performed on animals bred for many generations …

Dietary restriction (DR) is the most consistent means of extending life span throughout the
animal kingdom. Multiple mechanisms by which DR may act have been proposed but none …

Background Dietary restriction (DR) increases life span and delays age-associated disease
in many organisms. The mechanism by which DR enhances longevity is not well …

Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends
lifespan in a variety of species; however, its underlying mechanisms remain unclear. We …

The nematode Caenorhabditis elegans continues to serve as a useful model of life
extension caused by dietary restriction. Using this model, downstream effectors of dietary …

Diet is one of the more variable aspects in life due to the variety of options that organisms
are exposed to in their natural habitats. In the laboratory, C. elegans are raised on bacterial …