Anti-dsDNA B cells are actively tolerized in nonautoimmune BALB/c mice, as manifested by
their developmental arrest, follicular exclusion, and rapid turnover rate. Previously, we have …

Spleen and bone marrow (BM) are the major sites of antibody production and anamnestic
response in systemically immunized mice. We examined the VDJ segment repertoire of …

Recent work on B cell tolerance and autoimmunity has suggested the L chain allelic
inclusion is a property of autoreactive B cells and is closely linked to receptor editing. Allelic …

An enormous number of B cells with different B‐cell receptors (BCR s) are continuously
produced in the bone marrow. BCR s are further diversified during the germinal center …

Immunization with a T cell-dependent antigen (Ag) induces the B cell clones bearing the
appropriate antigenic specificity to initiate the formation of germinal centers (GC) where they …

We have previously constructed knock‐in (C57BL/6× BALB/c) F1 mice, each expressing an
anti‐DNA heavy (H) chain (D42), combined with one of three different light (L) chains …

Linked recognition of Ag by B and T lymphocytes is ensured in part by a state of tolerance
acquired by CD4 T cells to germline-encoded sequences within the B cell Ag receptor …

In an effort to increase the B-cell repertoire, tolerance induction in immature B-cells is
hypothesized to occur through" editing" of autoreactive receptors, a mechanism distinct from …

B cell activation versus anergy; the antigen receptor as a molecular switch - ScienceDirect
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