In this review, the authors analyze international trends in rates of neural tube defects (NTDs)
during the past three decades. Polulation-based data sources include the Metropolian …

Background: Folic acid is known to reduce risk of neural tube defects (NTDs). Even so, NTDs
continue to occur despite individual supplementation or population fortification with folic …

OBJECTIVE. Neural tube defects (NTDs) are preventable through preconceptional and
periconceptional folic acid intake. Although decreases in the prevalence of NTDs have been …

ABSTRACT The US Public Health Service recommends that all women in the United States
who might possibly become pregnant should consume 0.4 mg folic acid/d to lower the …

Neural tube defects (NTDs) are common fetal malformations. They are multifactorial in
origin, with folic acid as the primary known environmental factor. It is recommended that all …

Background Folate metabolism pathway genes have been examined for association with
neural tube defects (NTDs) because folic acid supplementation reduces the risk of this …

Randomized trials, supported by many observational studies, have shown that
periconceptional use of folic acid, alone or in multivitamin supplements, is effective for the …

Neural tube defects (NTDs), a common birth defect in humans, result from the failure of the
embryonic neural tube (NT) to close properly. NT closure is a complex, poorly understood …

BACKGROUND: It is well established that women who have had a pregnancy affected by a
neural tube defect (NTD) have an elevated risk of a subsequent NTD‐affected pregnancy …

Neural tube defects (NTDs) represent a common group of severe congenital malformations
that result from failure of neural tube closure during early development. Their etiology is …