Maternal vitamin levels during pregnancies producing infants with neural tube defects

JL Mills, J Tuomilehto, FY Kai, N Colman… - The Journal of …, 1992 - Elsevier
Women at very high risk for having a child with a neural tube defect (NTD) because they had
previously delivered affected children significantly reduced their recurrence rate by taking …

Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile

JS López‐Camelo, IM Orioli, MG Dutra… - American Journal of …, 2005 - Wiley Online Library
To verify whether the decreasing neural tube defects birth prevalence rates in Chile are due
to folic acid fortification or to pre‐existing decreasing trends, we performed a population …

Folic acid for the prevention of neural tube defects

American Academy of Pediatrics Committee on … - Pediatrics, 1999 - cir.nii.ac.jp
抄録< jats: p> The American Academy of Pediatrics endorses the US Public Health Service
(USPHS) recommendation that all women capable of becoming pregnant consume 400 μg …

Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case–control study

M Candito, R Rivet, B Herbeth… - American Journal of …, 2008 - Wiley Online Library
Neural tube defects (NTDs) are severe congenital malformations due to failure of neural
tube formation in early pregnancy. The proof that folic acid prevents NTDs raises the …

Prevention of neural tube defects in the UK: a missed opportunity

JK Morris, J Rankin, ES Draper, JJ Kurinczuk… - Archives of disease in …, 2016 - adc.bmj.com
Objective In 1991, the Medical Research Council (MRC) Vitamin Study demonstrated that
folic acid taken before pregnancy and in early pregnancy reduced the risk of a neural tube …

Is excess folic acid supplementation a risk factor for autism?

CM Beard, LA Panser, SK Katusic - Medical hypotheses, 2011 - Elsevier
BACKGROUND: The objective was to assess the association between increasing autism
incidence rates and the increasing dose of folic acid in prescription prenatal and pediatric …

Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects

B Christensen, L Arbour, P Tran… - American journal of …, 1999 - Wiley Online Library
Folic acid administration to women in the periconceptional period reduces the occurrence of
neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding …

Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid

HB Heseker, JB Mason, J Selhub… - British Journal of …, 2008 - cambridge.org
Some countries have introduced mandatory folic acid fortification, whereas others support
periconceptional supplementation of women in childbearing age. Several European …

Gene–gene interaction in folate-related genes and risk of neural tube defects in a UK population

CL Relton, CS Wilding, MS Pearce… - Journal of medical …, 2004 - jmg.bmj.com
Objective: To investigate the contribution of polymorphic variation in genes involved in the
folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD) …

Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects

MA Honein, LJ Paulozzi, TJ Mathews, JD Erickson… - Jama, 2001 - jamanetwork.com
ContextDaily consumption of 400 µg of folic acid before conception and during early
pregnancy dramatically reduces the occurrence of neural tube defects (NTDs). Before food …