Primary prevention of neural-tube defects and some other major congenital abnormalities: recommendations for the appropriate use of folic acid during pregnancy

AE Czeizel - Paediatric drugs, 2000 - Springer
Neural-tube defects (NTDs) are common and serious congenital abnormalities of the central
nervous system. Although some cases of NTDs are induced by hyperhomocysteinaemia …

Acid folic and pregnancy: A mandatory supplementation

M Valentin, PC Mazeau, M Zerah, PF Ceccaldi… - Annales d' …, 2018 - Elsevier
Neural tube defects (NTD) occur in 0.5 to 2 per 1000 pregnancies with various handicaps for
the affected child. It is now well established that folic acid deficiency (absolute or relative) is …

[HTML][HTML] Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature

T Zhang, J Lou, R Zhong, J Wu, L Zou, Y Sun, X Lu… - PLos one, 2013 - journals.plos.org
Background Neural Tube Defects (NTDs) are among the most prevalent and most severe
congenital malformations worldwide. Polymorphisms in key genes involving the folate …

Folate‐mediated one‐carbon metabolism and neural tube defects: Balancing genome synthesis and gene expression

AE Beaudin, PJ Stover - Birth Defects Research Part C: Embryo …, 2007 - Wiley Online Library
Neural tube defects (NTDs) refer to a cluster of neurodevelopmental conditions associated
with failure of neural tube closure during embryonic development. Worldwide prevalence of …

Overview on neural tube defects: From development to physical characteristics

L Avagliano, V Massa, TM George… - Birth defects …, 2019 - Wiley Online Library
Neural tube defects (NTDs) are the second most common congenital malformations in
humans affecting the development of the central nervous system. Although NTD …

A population‐based case–control study of risk factors for neural tube defects in four high‐prevalence areas of Shanxi province, China

Z Li, A Ren, L Zhang, Z Guo, Z Li - Paediatric and perinatal …, 2006 - Wiley Online Library
Summary Shanxi province in Northern China has one of the highest reported prevalence
rates of neural tube defects (NTD) in the world. To explore the risk factors for NTDs in Shanxi …

Apparent lability of neural tube closure in laboratory animals and humans

JM DeSesso, AR Scialli… - American journal of …, 1999 - Wiley Online Library
Neural tube defects (NTDs), a set of structural abnormalities affecting the brain, spinal cord,
and the skeletal and connective tissues that protect them, are common malformations …

Genetic, epigenetic, and environmental contributions to neural tube closure

JJ Wilde, JR Petersen, L Niswander - Annual review of genetics, 2014 - annualreviews.org
The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Reproductive factors, subfertility, and risk of neural tube defects: a case-control study based on the Oxford Record Linkage Study Register

D Whiteman, M Murphy, K Hey… - American journal of …, 2000 - academic.oup.com
Periconceptual exposure to subfertility treatments is increasingly common, raising concerns
about the possibility of malformations in the offspring. The authors conducted a case-control …

Evidence for multi‐site closure of the neural tube in humans

MI Van Allen, DK Kalousek, GF Chernoff… - American journal of …, 1993 - Wiley Online Library
Four separate initiation sites for neural tube (NT) fusion have been demonstrated recently in
mice and other experimental animals. We evaluated the question of whether the mult‐site …