Dietary restriction (DR) is the most consistent means of extending life span throughout the
animal kingdom. Multiple mechanisms by which DR may act have been proposed but none …

Culture in axenic medium causes two-fold increases in the length of development and adult
life span in Caenorhabditis elegans. We asked whether axenic medium imposes dietary …

The nematode Caenorhabditis elegans continues to serve as a useful model of life
extension caused by dietary restriction. Using this model, downstream effectors of dietary …

In Caenorhabditis elegans, several manipulations that affect nutrition slow development,
reduce fecundity, and increase life span. These are viewed as dietary restriction (DR) and …

The first observation of the positive effect of reduced food intake on mammalian life span
was made 70 years ago (1). In the decades that followed, researchers successfully applied …

Background Dietary restriction (DR) increases life span and delays age-associated disease
in many organisms. The mechanism by which DR enhances longevity is not well …

The nematode Caenorhabditis elegans has been subjected to DR by food (Escherichia coli)
dilution, growth in axenic medium and using animals having defects in feeding behavior or …

Dietary restriction is known to promote longevity in a variety of eukaryotic organisms. Most
studies of dietary restriction have been performed on animals bred for many generations …

The nematode Caenorhabditis elegans has proved to be an excellent model organism for
the study of development and aging. Many aging mutants have been discovered in the past …

Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends
lifespan in a variety of species; however, its underlying mechanisms remain unclear. We …