The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Activation of the transcription factor NF-κB is controlled by the sequential phosphorylation,
ubiquitination, and degradation of its inhibitory subunit, IκB. We recently purified a large …

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of
two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

The IκB kinase (IKK) complex mediates activation of transcription factor NF-κB by
phosphorylation of IκB proteins. Its catalytic subunits, IKKα and IKKβ, require association …

The NF-κB family of transcription factors plays a crucial role in the immune, inflammatory and
apoptotic responses. These proteins are normally found in the cytoplasm, retained by …

Transcription factors of the NF-κB family regulate hundreds of genes in the context of
multiple important physiological and pathological processes. NF-κB activation depends on …

NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …