IKKβ/IKBKB (IκB kinase beta), also designated as IKK2, was named after its function of
phosphorylating IκB molecules, the inhibitors of NF-κB transcription factors. The kinase …

Two related kinases, IκB kinase α (IKKα) and IKKβ, phosphorylate the IκB proteins, leading
to their degradation and the subsequent activation of gene expression by NF-κB. IKKβ has a …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

NF-κB is activated by various stimuli including inflammatory cytokines and stresses. A key
step in the activation of NF-κB is the phosphorylation of its inhibitors, IκBs, by an IκB kinase …

ABSTRACT IκB kinases (IKKα and IKKβ) are key components of the IKK complex that
mediates activation of the transcription factor NF-κB in response to extracellular stimuli such …

Protein kinases that regulate the activity of specific transcription factors in response to
extracellular stimuli not only are the subject of intense research but also are being chased …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

Nuclear factor kappa B (NF-κB) is a ubiquitous, inducible transcription factor that regulates
the initiation and progression of immune and inflammatory stress responses. NF-κB …

NF-κB is sequestered in the cytoplasm by the inhibitory IκB proteins. Stimulation of cells by
agonists leads to the rapid phosphorylation of IκBs leading to their degradation that results …

Activation of the transcription factor NF-κB is controlled by the sequential phosphorylation,
ubiquitination, and degradation of its inhibitory subunit, IκB. We recently purified a large …