Nuclear factor κB (NF-κB) has been studied extensively as an inducible transcriptional
regulator of the immune and inflammatory response. NF-κB activation downstream of …

The IKKβ and NEMO/IKKγ subunits of the NF-κB-activating signalsome complex are known
to be essential for activating NF-κB by inflammatory and other stress-like stimuli. However …

NF-κB in defense and disease serine residues. Phosphorylated IκBα is then ubiquitinated,
which targets it for degradation by the 26S proteasome (13), thereby releasing NF-κB dimers …

Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and
molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the …

Transcription factors of the NF-κB family regulate hundreds of genes in the context of
multiple important physiological and pathological processes. NF-κB activation depends on …

Activation of the transcription factor NF-κB by inflammatory cytokines involves the successive
action of NF-κB-inducing kinase (NIK) and two IκB kinases, IKK-α and IKK-β. Here we show …

NF-κB is sequestered in the cytoplasm by the inhibitory IκB proteins. Stimulation of cells by
agonists leads to the rapid phosphorylation of IκBs leading to their degradation that results …

Phosphatidylinositol 3′-kinase (PI3K) and the serine/threonine kinase AKT have critical
roles in phosphorylating and transactivating the p65 subunit of nuclear factor κB (NF-κB) in …

Canonical activation of NF-κB is mediated via phosphorylation of the inhibitory IκB proteins
by the IκB kinase complex (IKK). IKK is composed of a heterodimer of the catalytic IKKα and …

Distinct signaling pathways activate the NF-κB family of transcription factors. The canonical
NF-κB-signaling pathway is mediated by IκB kinase 2/β (IKK2/β), while the non-canonical …