The nuclear factor (NF)-κB pathway is important for the expression of a wide variety of genes
that are involved in the control of the host immune and inflammatory response, and in the …

The IκB-Kinase (IKK) complex is a multisubunit protein complex crucial for signal-induced
phosphorylation of the IκB proteins and thus controls the activity of the transcription factor NF …

Phosphorylation of IκB by the IκB kinase (IKK) complex is a critical step leading to IκB
degradation and activation of transcription factor NF-κB. The IKK complex contains two …

The IκB kinase (IKK) complex is involved in transcriptional activation by phosphorylating the
inhibitory molecule IκBα, a modification that triggers its subsequent degradation, enabling …

The signaling module that specifies nuclear factor‐κΒ (NF‐κB) activation is a three‐
component system: NF‐κB, inhibitor of NF‐κΒ (IκΒ), and IκΒ kinase complex (IKK). IKK …

The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the
transcriptional responses of physiological processes that include cell division, cell survival …

IκB kinase γ (IKKγ)(also known as NEMO, Fip-3, and IKKAP-1) is the essential regulatory
component of the IKK complex; it is required for NF-κB activation by various stimuli, including …

Proinflammatory activation of NF-κB requires an upstream kinase complex (IκB-kinase; IKK)
composed of two catalytic subunits (IKKα and IKKβ) and a noncatalytic regulatory …

The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

The diverse cellular and biological functions of the nuclear factor kappa B (NF-κB) pathway,
together with the catastrophic consequences of its aberrant regulation, demand specific and …