Rel/NF-kB transcription factors include a collection of proteins, conserved from Drosophila to
humans (Figure 1). Among model organisms, these transcription factors are notably absent …

Here we report the identification of a novel PMA-inducible IκB kinase complex, distinct from
the well-characterized high–molecular weight IκB kinase complex containing IKKα, IKKβ …

The innate immune system forms our first line of defense against invading pathogens and
relies for a major part on the activation of two transcription factors, NF-κB and IRF3 …

The importance of the IκB kinase (IKK)/NF-κB signaling pathway in immunoregulatory
functions is well accepted. However, the relevance of IKK and NF-κB in tumor maintenance …

The IκB kinase (IKK) complex is composed of three subunits, IKKα, IKKβ, and IKKγ (NEMO).
While IKKα and IKKβ are highly similar catalytic subunits, both capable of IκB …

Nuclear factor-κB (NF-κB)/Rel transcription factors have been suspected since their
discovery to play a pivotal role in chronic and acute inflammatory diseases. It now seems …

Phosphatidylinositol (PI) 3-kinase/Akt signaling activates NF-κB through pleiotropic, cell type-
specific mechanisms. This study investigated the significance of PI 3-kinase/Akt signaling to …

The past two decades have led to a tremendous work on the transcription factor NF-κB and
its molecular mechanisms of activation. The nuclear translocation of NF-κB is controlled by …

ABSTRACT NF-κB corresponds to an inducible eukaryotic transcription factor complex that
is negatively regulated in resting cells by its physical assembly with a family of cytoplasmic …

Nuclear factor kappa B (NF-κB)/Rel proteins are dimeric, sequence-specific transcription
factors involved in the activation of an exceptionally large number of genes in response to …