The IκB kinase (IKK) complex, composed of two catalytic subunits (IKKα and IKKβ) and a
regulatory subunit (IKKγ), is the key enzyme in activation of nuclear factor κB (NF-κB). To …

Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the
canonical pathway that mediates inflammatory responses, and the non-canonical pathway …

IκB kinase (IKK) complex plays a key regulatory role in macrophages for NF-κB activation
during both innate and adaptive immune responses. Because IKK1–/–mice died at birth, we …

The IκB kinase (IKK) complex serves as the master regulator for the activation of NF‐κB by
various stimuli. It contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit …

The transcription factor NF-κB plays an important role in both physiological and pathological
events in the central nervous system. Nevertheless, the mechanisms of NF-κB-mediated …

NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …

Here we identify IKKϵ as a novel NF-κB p65 kinase that mediates inducible phosphorylation
of Ser 468 and Ser 536 in response to T cell costimulation. In addition, the kinase activity of …

In mammals, the canonical nuclear factor κB (NF-κB) signaling pathway activated in
response to infections is based on degradation of IκB inhibitors. This pathway depends on …

Inflammation and innate immunity involve signalling pathways leading to the production of
inflammatory mediators. Usually such responses are self-limiting, but aberrant resolution of …

The IκB kinases (IKKs) lie downstream of the NF-κB-inducing kinase (NIK) and activate NF-
κB by phosphorylation of IκBα. This leads to IκBα degradation and release of NF-κB. In U937 …