James Parkinson has been credited for almost 200 years with establishing the major clinical
features of Parkinson's disease (PD), and we remain in awe of his observational and …

Abstract Background: In 2015, the International Parkinson and Movement Disorder Society
published clinical diagnostic criteria for Parkinson's disease. These criteria aimed to …

There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive
impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD …

The identification of the widespread deposition of fibrillized α‐synuclein in Lewy bodies and
Lewy neurites in the brains of patients with Parkinson's disease in 1997 has had a profound …

Nonmotor symptoms occur commonly in Parkinson's disease (PD) patients and are
frequently under-recognized and undertreated. Symptoms include sleep abnormalities …

OBJECTIVE: To characterize fatigue in Parkinson's disease (PD). BACKGROUND: Fatigue
is a recognized problem in PD. Fatigue can be in the physical realm or in the mental realm …

Nonmotor symptoms (NMSs) commonly occur in Parkinson's disease (PD). This study
sought to explore the domains of NMSs that are more closely related to PD using nonmotor …

Although case histories of depression preceding Parkinson's disease (PD) point to a
possible pathophysiological relationship between these two disorders, there is as yet no …

Objective: To determine progression and prognostic factors of progression rate of motor
impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's …

Relatively subtle deterioration of the motor system likely occurs well before the patient meets
established motor criteria for a clinical diagnosis of Parkinson's disease; ie, the occurrence …