The role of folate transport and metabolism in neural tube defect risk
RC Barber, EJ Lammer, GM Shaw, KA Greer… - Molecular genetics and …, 1999 - Elsevier
Neural tube defects (NTDs) are common congenital malformations in humans. While
etiologically heterogeneous, for the most part they are multifactorial in their pathogenesis …
etiologically heterogeneous, for the most part they are multifactorial in their pathogenesis …
Genetic risk factors for folate-responsive neural tube defects
Neural tube defects (NTDs) are the most severe congenital malformations of the central
nervous system. The etiology is complex, with both genetic and environmental factors …
nervous system. The etiology is complex, with both genetic and environmental factors …
Insights into metabolic mechanisms underlying folate‐responsive neural tube defects: a minireview
AE Beaudin, PJ Stover - Birth Defects Research Part A: Clinical …, 2009 - Wiley Online Library
Neural tube defects (NTDs), including anencephaly and spina bifida, arise from the failure of
neurulation during early embryonic development. Neural tube defects are common birth …
neurulation during early embryonic development. Neural tube defects are common birth …
Investigations into the etiology of neural tube defects
RM Cabrera, DS Hill, AJ Etheredge… - Birth Defects Research …, 2004 - Wiley Online Library
Neural tube defects (NTDs) are serious malformations affecting approximately 1 per 1000
births, yet the mechanisms by which they arise are unknown. There have been consistent …
births, yet the mechanisms by which they arise are unknown. There have been consistent …
Abnormal folate metabolism in foetuses affected by neural tube defects
LPE Dunlevy, LS Chitty, KA Burren, K Doudney… - Brain, 2007 - academic.oup.com
Folic acid supplementation can prevent many cases of neural tube defects (NTDs), whereas
suboptimal maternal folate status is a risk factor, suggesting that folate metabolism is a key …
suboptimal maternal folate status is a risk factor, suggesting that folate metabolism is a key …
Neural tube defects, folic acid and methylation
A Imbard, JF Benoist, HJ Blom - International journal of environmental …, 2013 - mdpi.com
Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …
failure of the neural tube closure during embryogenesis. It is established that folic acid …
Folate‐mediated one‐carbon metabolism and neural tube defects: Balancing genome synthesis and gene expression
AE Beaudin, PJ Stover - Birth Defects Research Part C: Embryo …, 2007 - Wiley Online Library
Neural tube defects (NTDs) refer to a cluster of neurodevelopmental conditions associated
with failure of neural tube closure during embryonic development. Worldwide prevalence of …
with failure of neural tube closure during embryonic development. Worldwide prevalence of …
Human neural tube defects: genetic causes and prevention
Neural tube defects (NTDs) are severe congenital malformations affecting 1–2 in 1,000 live
births, whose etiology is multifactorial, involving environmental and genetic factors. NTDs …
births, whose etiology is multifactorial, involving environmental and genetic factors. NTDs …
[PDF][PDF] Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects
K Doudney, J Grinham, J Whittaker… - American Journal of …, 2009 - theshinelibrary.org
Neural tube defects (NTDs) are among the commonest human birth defects, affecting around
1 per 1,000 births [Copp et al., 2003]. A genetic basis for NTDs is implicated based on the …
1 per 1,000 births [Copp et al., 2003]. A genetic basis for NTDs is implicated based on the …
Folate and epigenetic mechanisms in neural tube development and defects
SV Meethal, KJ Hogan, CS Mayanil, BJ Iskandar - Child's nervous system, 2013 - Springer
Introduction Multiple genetic and epigenetic factors involved in central nervous system
(CNS) development influence the incidence of neural tube defects (NTDs). Discussion The …
(CNS) development influence the incidence of neural tube defects (NTDs). Discussion The …