NF-κB plays a central role in cytokine-inducible inflammatory gene expression. Previously
we empirically determined the identity of 92 members of the genetic network under direct NF …

NF-KB and the other members of the Rel family of transcriptional activator proteins have
been a focal point for understanding how extracellular signals induce the expression of …

Tumor necrosis factor-α (TNF-α) and lymphotoxin-β receptor (LTβR) signaling both play
important roles in inflammatory and immune responses through activation of NF-κB. Using …

The NF-κB family members p65 (RelA) and c-Rel recognize similar DNA sequences, yet the
phenotypes of mutant mice suggest that these proteins regulate distinct sets of genes. Here …

The NF-κB transcription factor p50 and the Rel protein-specific transcription inhibitor p105
are both encoded by the nfkb1 gene. The p50 protein is incorporated within the N-terminal …

TNF-α is a potent proinflammatory cytokine that regulates immune and inflammatory
responses and programmed cell death. TNF-α stimulation causes nuclear translocation of …

A novel member of the IκB family has been identified as a protein that associated with the
p50 subunit of NF-κB in a yeast two-hybrid screen. Similar to previously known IκB proteins …

The NF-κB signalling module controls transcription through a network of protein kinases
such as the IKKs, as well as inhibitory proteins (IκBs) and transcription factors including …

Nuclear factor-κB (NF-κB) is tightly modulated by IκB kinases and IκBα in the cytoplasm. On
stimulation, NF-κB translocates into the nucleus to initiate transcription; however, regulation …

The X‐ray structure of the nuclear factor‐κB (NF‐κB) p52: RelB: κB DNA complex reveals a
new recognition feature not previously seen in other NF‐κB: κB DNA complexes. Arg 125 of …