A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK)
complex. IKKα and IKKβ are the two catalytic subunits of the IKK complex and two additional …

Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and
molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the …

Activation of the transcription factor NF-κB is controlled by the sequential phosphorylation,
ubiquitination, and degradation of its inhibitory subunit, IκB. We recently purified a large …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

IKKγ/NEMO is an essential regulatory component of the IκB kinase complex that is required
for NF-κB activation in response to various stimuli including tumor necrosis factor-α and …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Two related kinases, IκB kinase α (IKKα) and IKKβ, phosphorylate the IκB proteins, leading
to their degradation and the subsequent activation of gene expression by NF-κB. IKKβ has a …

NF-κB is activated by various stimuli including inflammatory cytokines and stresses. A key
step in the activation of NF-κB is the phosphorylation of its inhibitors, IκBs, by an IκB kinase …

The IκB kinase (IKK) complex mediates activation of transcription factor NF-κB by
phosphorylation of IκB proteins. Its catalytic subunits, IKKα and IKKβ, require association …

Recent investigations have elucidated the cytokine-induced NF-κB activation pathway. IκB
kinase (IKK) phosphorylates inhibitors of NF-κB (IκBs). The phosphorylation targets them for …