Activation of the transcription factor NF-κB is controlled by the sequential phosphorylation,
ubiquitination, and degradation of its inhibitory subunit, IκB. We recently purified a large …

Signal-induced nuclear expression of the eukaryotic NF-κB transcription factor involves the
stimulatory action of select mitogen-activated protein kinase kinase kinases on the IκB …

A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK)
complex. IKKα and IKKβ are the two catalytic subunits of the IKK complex and two additional …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Recent investigations have elucidated the cytokine-induced NF-κB activation pathway. IκB
kinase (IKK) phosphorylates inhibitors of NF-κB (IκBs). The phosphorylation targets them for …

The IκB kinase (IKK) complex mediates activation of transcription factor NF-κB by
phosphorylation of IκB proteins. Its catalytic subunits, IKKα and IKKβ, require association …

Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and
molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the …

The NF-κB family of transcription factors plays a crucial role in the immune, inflammatory and
apoptotic responses. These proteins are normally found in the cytoplasm, retained by …

IKKγ/NEMO is a protein that is critical for the assembly of the high molecular weight IκB
kinase (IKK) complex. To investigate the role of IKKγ/NEMO in the assembly of the IKK …