This study aimed to clarify the efficacy, safety, and pharmacokinetics of piperacillin–
tazobactam (PIPC–TAZ) in late elderly Japanese patients. This is the first antimicrobial pilot …

Background Sepsis is a common diagnosis in critical care with inpatient mortality rates up to
50%. Sepsis care is organized around source control, antibiotics, and supportive care. Drug …

Background Prolonged infusion of beta-lactam antibiotics is broadly recognized as a
strategy to optimize antibiotic therapy by achieving a higher percentage of time that …

Background Recently, continuous administration of piperacillin-tazobactam has been
proposed as a valuable alternative to traditional intermittent administration especially in …

Objectives To assess the relationship between renal function and efficacy/safety of
imipenem/cilastatin/relebactam for the treatment of hospital-acquired/ventilator-associated …

Background: ß-Lactam antibiotics are reported to exhibit time-dependent bactericidal
activity. However, there are limited data on the clinical efficacy of ceftazidime administered …

Objective The aim of this study was to compare the usefulness of cefoperazone-sulbactam
and that of piperacillin-tazobactam in the treatment of hospital-acquired pneumonia (HAP) …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with
acute kidney injury treated with continuous renal replacement therapy (CRRT). However …

Objective We conducted a prospective, open-label study to determine the steady-state
serum and epithelial lining fluid (ELF) concentrations of unbound ertapenem administered …