Induction immunosuppression

AD Kirk - Transplantation, 2006 - journals.lww.com
Induction immunosuppression is intense, prophylactic therapy used at the time of
transplantation based on the empiric observation that more powerful immunosuppression is …

Induction immunosuppression improves long-term graft and patient outcome in organ transplantation: an analysis of United Network for Organ Sharing registry data

J Cai, PI Terasaki - Transplantation, 2010 - journals.lww.com
Background. Induction agents have been shown to reduce the rate of acute rejection. They
have not been clearly shown to improve graft and patient survival. Methods. United Network …

New directions for induction immunosuppression strategy in solid organ transplantation

JS Hawksworth, D Leeser, RM Jindal, E Falta… - The American journal of …, 2009 - Elsevier
BACKGROUND: Solid organ transplant centers are increasingly using induction
immunosuppression strategies. Induction immunosuppression involves the use of intense …

Induction immunosuppressive therapies in renal transplantation

S Gabardi, ST Martin, KL Roberts… - American Journal of …, 2011 - academic.oup.com
Purpose Induction immunosuppressive therapies for patients undergoing renal
transplantation are reviewed. Summary The goal of induction therapy is to prevent acute …

Selection of induction therapy in kidney transplantation

KL Hardinger, DC Brennan, CL Klein - Transplant International, 2013 - Wiley Online Library
Currently available immunosuppressive agents can be classified into three categories:
induction agents, maintenance therapy, and treatment for rejection. This review article will …

To induce or not to induce: do patients at greatest risk for fatal rejection benefit from cytolytic induction therapy?

R Higgins, JK Kirklin, RN Brown, BK Rayburn… - The Journal of heart and …, 2005 - Elsevier
BACKGROUND: Induction immunosuppression utilizing lymphocytolytic agents in the early
peri-operative period has a number of theoretical and practical advantages and …

Anti‐IL‐2 receptor antibody vs. polyclonal anti‐lymphocyte antibody as induction therapy in pediatric transplantation

S Di Filippo - Pediatric transplantation, 2005 - Wiley Online Library
Current concerns in pediatric transplantation focus on chronic rejection which commonly
leads to graft loss, and on long‐term maintenance immunosuppression toxicity. Acute …

Strategies for minimizing immunosuppression in kidney transplantation

AD Kirk, RB Mannon, S John Swanson… - Transplant …, 2005 - Wiley Online Library
Immunosuppression remains the cause of most morbidity following organ transplantation.
However, its use is also responsible for the outstanding graft and patient survival rates …

Immunosuppressive agents

BD Kahan, R Ghobrial - Surgical clinics of North America, 1994 - Elsevier
The present success of organ transplantation is largely due to advances in
immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated …

The need for minimization strategies: current problems of immunosuppression

J Bamoulid, O Staeck, F Halleck… - Transplant …, 2015 - Wiley Online Library
New immunosuppressants and the better use of immunosuppressant combination therapy
have led to significant improvements in renal allograft outcomes over the last decades. Yet …