Easy and effective vaccination methods could reduce mortality rates and morbidity due to
vaccine-preventable influenza infections. In this study, we examined the use of microneedle …

Background Simple and effective vaccine administration is particularly important for annually
recommended influenza vaccination. We hypothesized that vaccine delivery to the skin …

To address the limitations of conventional influenza vaccine manufacturing and delivery, this
study investigated administration of virus-like particle (VLP) influenza vaccine using a …

Influenza infection represents a major socio-economic burden worldwide. Novel delivery
methods can render influenza vaccination easier and more acceptable by the public and …

The emergence of the swine-origin 2009 influenza pandemic illustrates the need for
improved vaccine production and delivery strategies. Skin-based immunization represents …

Microneedle patches (MN) provide a novel method of vaccine delivery to the skin with the
objective of targeting the large network of resident antigen-presenting cells to induce an …

Background. Morbidity and mortality due to influenza could be reduced by improved
vaccination. Methods. To develop a novel skin delivery method that is simple and allows for …

Skin vaccination with influenza virus-like particles (VLPs) using microneedles has been
shown to induce protection similar to or better than that induced by intramuscular …

Influenza prophylaxis would benefit from a simple method to administer influenza vaccine
into skin without the need for hypodermic needles. In this study, solid metal microneedle …

The threat of pandemic influenza and other public health needs motivate the development of
better vaccine delivery systems. To address this need, microneedles have been developed …